Bill Cara’s Daily Global Pulse Report, September 12, 2025

Sidestepping Pharma’s Pfizer, While Riding the Quantum Wave With Rigetti

R-88 Performance Snapshot

(1) Top 3 (1-Day %)

• Rigetti Computing Inc (RGTI): 14.38%

• Quantumscape Corp (QS): 12.43%

• Grab Holdings Ltd (GRAB): 8.41%

(2) Bottom 3 (1-Day %)

• Oracle Corporation (ORCL): -5.09%

• DraftKings Inc (DKNG): -4.12%

• Pfizer Inc (PFE): -3.94%

(3) Top 3 (1-Week %)

• Opendoor Technologies Inc (OPEN): 36.08%

• Applied Digital Corp (APLD): 34.49%

• Rigetti Computing Inc (RGTI): 26.42%

(4) Bottom 3 (1-Week %)

• Diageo PLC ADR (DEO): -7.74%

• Pinterest Inc (PINS): -7.67%

• Deutsche Telekom AG ADR (DTEGY): -5.32%

(5) Top 3 (1-Month %)

• Opendoor Technologies Inc (OPEN): 273.93%

• Hims Hers Health Inc (HIMS): 14.84%

• Agnico Eagle Mines Limited (AEM): 14.64%

(6) Bottom 3 (1-Month %)

• CSL Ltd (CSLLY): -22.79%

• Joby Aviation (JOBY): -21.36%

• MicroStrategy Incorporated (MSTR): -15.00%

Quantitative Anomalies & INSTAT Analysis

1. Opendoor Technologies Inc (OPEN): This stock exhibits a significant price anomaly with a 1-Day change of -13.99% and a 1-Month change of 273.93%, surpassing the threshold of |1 Month| ≥ 15%. The INSTAT scores show a Bearish Cyclic Alert (AT negative: -2, ST positive: 47). This combination suggests algorithmic selling pressure in the short term, conflicting with positive swing trader momentum, indicating potential volatility as short-term technicals remain strong despite intra-day selling.

2. Rigetti Computing Inc (RGTI): A notable price anomaly is observed with a 1-Day change of 14.38% and a 1-Year change of 2139.03%, exceeding the |1 Year| ≥ 50% threshold. The INSTAT scores reflect a STRONG BUY signal (AT: 24, ST: 50, IN: 50, Total: 100), indicating consistent bullish sentiment across all timeframes. This suggests robust institutional and algorithmic buying, reinforcing a strong upward trend.

3. Joby Aviation (JOBY): This stock shows a price anomaly with a 1-Month change of -21.36%, meeting the |1 Month| ≥ 15% threshold. The INSTAT scores indicate a Bearish Trend Alert (ST negative: 14, IN positive: 48). This suggests short-term technical weakness against longer-term institutional strength, potentially signaling a reversal opportunity as institutional positioning remains supportive despite recent price declines.

Bill Cara’s Perspective & Recommendations

The R-88 Global Pulse Report reveals a dynamic market with strong performers in innovative sectors like quantum computing and real estate technology, contrasted by underperformance in select traditional industries. Rigetti Computing Inc (RGTI) emerges as a STRONG BUY, driven by its remarkable 1-Day (14.38%) and 1-Year (2139.03%) performance, backed by a perfect INSTAT Total score of 100. Reuters highlights growing investor enthusiasm for quantum computing, with Rigetti positioned as a leader due to its advancements in scalable quantum systems. The alignment of positive AT, ST, and IN scores underscores a robust bullish trend, making RGTI a high-conviction choice for growth-focused portfolios.

Opendoor Technologies Inc (OPEN) merits a BUY recommendation despite a sharp 1-Day drop (-13.99%), given its extraordinary 1-Month gain (273.93%) and strong ST (47) and IN (50) scores. The Bearish Cyclic Alert suggests short-term algorithmic selling, but the sustained swing and institutional momentum indicate a tactical opportunity to add on weakness. Bloomberg reports Opendoor’s innovative real estate platform is attracting significant institutional capital, supporting its long-term growth potential.

Joby Aviation (JOBY) is assigned a HOLD/MONITOR recommendation. The 1-Month decline (-21.36%) and Bearish Trend Alert (ST: 14, IN: 48) signal near-term caution, but positive institutional scores suggest potential for recovery. The Financial Times notes increasing interest in electric vertical takeoff and landing (eVTOL) technologies, positioning Joby as a compelling long-term investment despite short-term challenges.

Conversely, Pfizer Inc (PFE) warrants an AVOID/SELL recommendation, with fully negative INSTAT scores (AT: -25, ST: -50, IN: -50, Total: -100) and consistent underperformance (1-Day: -3.94%, 1-Year: -18.41%). Barron’s cites ongoing challenges in Pfizer’s innovation pipeline, weighing on its outlook. Similarly, CSL Ltd (CSLLY) is recommended as AVOID/SELL due to its significant 1-Month decline (-22.79%) and fully negative INSTAT scores, signaling a bearish technical phase.

Investors should prioritize high-conviction opportunities like RGTI and OPEN, capitalizing on dips for accumulation, while remaining cautious with underperformers like PFE and CSLLY. Monitoring JOBY for institutional follow-through is advisable, given its long-term potential in the eVTOL space.

References

1. Reuters: “Quantum Computing Stocks Surge as Investors Bet on Next-Gen Tech,” September 2025.

2. Bloomberg: “Opendoor Gains Institutional Backing Amid Real Estate Disruption,” August 2025.

3. Financial Times: “eVTOL Sector Faces Turbulence but Long-Term Promise,” September 2025.

4. Barron’s: “Pharma Giants Struggle with Innovation Drought,” August 2025.

5. Wall Street Journal: “Market Volatility Highlights Sector Divergence,” September 2025.

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